Cognitive Disorders In People Living With Hiv The Lancet Hiv Purpose of review: the effect of hiv and aging on brain functions is an increasingly important topic of research: hiv infected (hiv ) persons aged ≥50 represent a growing part of the hiv epidemic. research is embracing this new axis, but there has been a lack of conceptualization of the factors that are at stake in both aging and hiv. Putative factors contributing to neurocognitive impairment and neuroimaging changes in the aging hiv brain, such as metabolic disturbances, cardiovascular risk factors, immune senescence, and neuroinflammation, are described. the possible relationship between hiv and some markers of alzheimer’s disease is presented.
Impact Of Hiv On Brain Structure And Function Neither markers of hiv (hiv viral load or cd4 cell count) nor degree of cognitive impairment associated with hiv correlated with rs fcmri measures. aging led to a decrease in correlations within the dmn (p=.03) and sal (p=.006) networks for both hiv and hiv subjects, however no interaction was present between hiv and aging. For several reasons, the effect of hiv on the aging brain has become the subject of much greater concern over the past decade. first, hiv has become a chronic illness, with infected people now having nearly normal life expectancy [ 20 ]. The control of hiv viremia by art has a remarkable positive effect on the ageing of plwh: it significantly prolongs their life expectancy and prevents aids and non aids related events, transforming hiv infection into a chronic and manageable condition. 31 furthermore, the start study showed the benefits of early art initiation, regardless of the immunological status, to prevent serious aids. This review will explore the topic of cognitive aging with hiv: 1. central nervous system (cns) infection of hiv and how the virus affects brain integrity and function; 2. cognitive and behavioral symptoms of hiv associated neurocognitive disorders (hand); 3. neurobiological theories of cognitive aging and how these processes may be exacerbated.
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